691 research outputs found

    Measuring brand image: Shopping centre case studies

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    'Branding' is well known for consumer products but power has shifted from manufacturers' brands towards retailers'. The term 'image' is more common than 'brand' in the context of shopping centres, but 'branding' may become more important. In this study, the authors first investigated qualitatively, asking shoppers to describe centres in 'personality' terms and eliciting clear descriptive differences between centres. For example, one in-town centre was 'dull, boring and old-fashioned . . . not exciting, just OK'; a larger regional centre was 'trendy, prestigious . . . strong, vibrant, big and colourful'. Second, the authors evaluated six UK shopping centres quantitatively using a questionnaire survey (n = 287). The 'strong and vibrant' centre scored significantly higher than the 'dull and boring' one. Despite 'branding' being little used by shopping centres, those with the better 'brand images' tended to have larger catchment areas, sales and rental incomes. The authors contend that brand management could pay rewards in terms of customer numbers, sales turnover and rental income

    Geodesic Warps by Conformal Mappings

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    In recent years there has been considerable interest in methods for diffeomorphic warping of images, with applications e.g.\ in medical imaging and evolutionary biology. The original work generally cited is that of the evolutionary biologist D'Arcy Wentworth Thompson, who demonstrated warps to deform images of one species into another. However, unlike the deformations in modern methods, which are drawn from the full set of diffeomorphism, he deliberately chose lower-dimensional sets of transformations, such as planar conformal mappings. In this paper we study warps of such conformal mappings. The approach is to equip the infinite dimensional manifold of conformal embeddings with a Riemannian metric, and then use the corresponding geodesic equation in order to obtain diffeomorphic warps. After deriving the geodesic equation, a numerical discretisation method is developed. Several examples of geodesic warps are then given. We also show that the equation admits totally geodesic solutions corresponding to scaling and translation, but not to affine transformations

    Politics, coercion and power : an analysis of economic failure in healthcare systems

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    This study examines notions of government and market failure in British healthcare by tracking and analysing the changing views of opinion formers. Presenting original data that highlights the attitudes of today's opinion formers towards populist notions in health economics it provides a unique insight into the limits and boundaries of contemporary debate. Significantly, the research concludes that swathes of elite opinion no longer support the National Health Service (NHS) in its traditional nationalised guise. While opinion formers instead now believe in a much greater plurality of public and private healthcare today's elite not only question the idea of state healthcare but they also remain sceptical of a purist libertarian market. Indeed, in noting that healthcare has always attracted the interventionist attentions of those with state power, the study questions in fundamental ways the meaning of such terms as 'market' and 'private sector'. In highlighting the timeless propensity for medical and health professionals to seek legislative favour, it argues that the world has never actually seen anything resembling a real market in the bio-medical paradigm and its forbears. Healthcare has always been a deeply corporatist venture run in association with a range of mystical, military, religious, or purely political statist elites. The study begins with an historical overview of healthcare from the military hospitals of the Roman period, through the religiosity of the Middle Ages, the mutuality of the nineteenth century, the statism of the National Health Service and the recent rise of public private partnerships. Examining such concepts as monopoly, consumer ignorance, moral hazard and externality, it also analyses notions of public versus private goods in the context of today's healthcare.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

    The epidemiological approach to sports injury : the case for rugby league

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    In any sporting activity it is important to know how many injuries players might receive and also what type of injuries will be received, so that efforts can be made to reduce the risk of injury. This thesis examines the injury incidence associated with playing professional rugby league, and examines some of the risks associated with injury whilst playing the game. The first paper describes the pattern of injury incidence in professional rugby league and noted that it is higher than in other popular team sports. The second paper examines the different exposures of forward and back players and observes that forwards experience higher rates of injury. The third and fourth papers examine the effect of moving the playing calendar to summer rugby. The risk of injury has increased 67%, and it is also shown that 13% of players experience a 2-3% body mass loss in 14 of 16 games played in excess of 19°C ambient temperature. The next two papers look specifically at the number of collisions experienced by players during the course of a game. Forwards are involved in more collisions (55) than backs (29) during the course of each game. Also, backs have a significantly higher injury rate per 10,000 physical collisions compared to forwards. The next paper proposes a cyclical operational model to examine the interrelationship of a number of factors that are involved in sports injury epidemiology. The application of this proposed cyclical model may lead to greater success in understanding the multi-faceted nature of sports injuries. The final study in the series summarise the injury rates in professional rugby league football from previously published studies. The overall injury rate is 40.3 injuries per 1,000 hours (95% CI 36.9 to 43.8). The majority of injuries are to the lower half of the body (20.7 per 1,000 hours, 17.7 to 24), with the trunk receiving the least (6.7 per 1,000 hours, 5 to 8.6).EThOS - Electronic Theses Online ServiceGBUnited Kingdo

    Retrospective case note review of chronic spontaneous urticaria outcomes and adverse effects in patients treated with omalizumab or ciclosporin in UK secondary care.

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    BACKGROUND: Omalizumab is approved in the UK as add-on treatment for chronic spontaneous urticaria (CSU) in patients with inadequate response to H1-antihistamines. Ciclosporin is an established but unlicensed 3rd line option for CSU. Two parallel retrospective observational studies were conducted to describe outcomes of treatment and adverse events with omalizumab or ciclosporin for CSU treatment. METHODS: Data from UK specialist centres prescribing omalizumab (five centres) or ciclosporin (three centres) in CSU patients were collected from hospital records by clinical staff and pooled for analysis. RESULTS: Forty-six patients prescribed omalizumab and 72 patients prescribed ciclosporin were included. Twenty-two (48%) omalizumab-treated patients had paired Urticaria Activity Scores (UAS7), showing a 25.4 point improvement during treatment (P < 0.0001). Paired Dermatology Life Quality Index (DLQI) was available in 28 (61%) omalizumab-treated and 17 (24%) ciclosporin-treated patients. At least a 75% improvement in DLQI score was observed in 79% of omalizumab-treated and 41% of ciclosporin-treated patients, and 65% of omalizumab-treated patients had complete resolution of their quality-of-life impairment (DLQI 0-1) versus 21% of ciclosporin-treated patients. Clinician comments reported symptom clearance in 15/36 (42%) omalizumab-treated and 10/60 (17%) ciclosporin-treated patients. Proportions of patients with adverse events were similar but those for omalizumab resembled CSU symptoms, making causality assignment difficult, whereas those for ciclosporin were consistent with its known adverse effect profile. CONCLUSIONS: Validated patient-reported measures of disease severity and quality of life should be used routinely in CSU management. Based on clinician comments and DLQI scores, symptoms and quality of life showed a greater improvement in the omalizumab-treated cohort than in the ciclosporin-treated cohort

    The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

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    We thank Manuel Kulagin for technical help, Pierre Bonnaventure for portal vein blood sampling, Francisco Sepulveda for technical assistance in GS-MS acquisition, and Dorothee Hahne (Metabolomics Australia, University of Western Australia) for human samples SCFA isolation, acquisition, and analysis. We also thank Cristina Cartoni (Phenotyping Unit, EPFL) for Milliplex analysis, Jessica Dessimoz and her team from the Histology Core Facility (EPFL), Miguel Garcia and his team from the Flow Cytometry Core Facility (EPFL), and staff from the EPFL CPG animal house for excellent animal care. The computations were partially performed at the Vital-IT Center for high-performance computing of the SIB Swiss Institute of Bioinformatics (http://www.vital-it.ch). The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013) / ERC Grant Agreement n. 310948. Funding for A.W.W. and a subset of the 16S rRNA gene sequencing was provided by the Wellcome Trust (grant number WT 098051). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
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